Complete list of publications:

Manso JA, Carabias A, Sárkány Z, de Pereda JM, Pereira PJB, Macedo-Ribeiro S. (2023) "Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets." mBio 14(4):e0063823. [PubMed] [doi: 10.1128/mbio.00638-23]
Also available in bioRxiv. 2022.08.23.504951. [doi: 10.1101/2022.08.23.504951]

Rodríguez-Blázquez A, Carabias A, Morán-Vaquero A, de Cima S, Luque-Ortega JR, Alfonso C, Schuck P, Manso JA, Macedo-Ribeiro S, Guerrero C, de Pereda JM (2023) "Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms." Cell Commun Signal 21(1):30. [PubMed] [doi: 10.1186/s12964-023-01042-2 ]
Also available in bioRxiv. 2022.11.24.515150. [doi: 10.1101/2022.11.24.515150 ]

Stam W, Wachholz GE, de Pereda JM, Kapur R, van der Schoot E, Margadant C (2023) "Fetal and neonatal alloimmune thrombocytopenia: Current pathophysiological insights and perspectives for future diagnostics and treatment." Blood Rev. 59:101038. [PubMed] [doi: 10.1016/j.blre.2022.101038]

Manso JA, Marcos T, Ruiz-Martín V, Casas J, Alcón P, Sánchez Crespo M, Bayón Y, de Pereda JM, Alonso A. (2022) "PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders." Cell. Mol. Life Sci. 79, 131. [PubMed] [doi: 10.1007/s00018-022-04173-w]

Te Molder L, de Pereda JM*, Sonnenberg A* (2021) "Regulation of hemidesmosome dynamics and cell signaling by integrin α6β4." J Cell Sci 134(18):jcs259004. [PubMed] [doi: 10.1242/jcs.259004]

Te Molder L, Kreft M, Heemskerk N, Schuring J, de Pereda JM, Wilhelmsen K, Sonnenberg A (2021) "EGFR-dependent tyrosine phosphorylation of integrin β4 is not required for downstream signaling events in cancer cell lines." Scientific Reports 11(1):8675. [PubMed] [doi: 10.1038/s41598-021-88134-6 ]

Carabias A, Guerrero C, de Pereda JM (2021) "C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies." Mol Cell Oncol. 8(1):1837581. [PubMed] [doi: 10.1080/23723556.2020.1837581]

Carabias A, Gómez-Hernández M, de Cima S, Rodríguez-Blázquez A, Morán-Vaquero A, González-Sáenz P, Guerrero C, de Pereda JM (2020) "Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas." Science Signaling 13(647):eabb7075. [PubMed] [doi: 10.1126/scisignal.abb7075]

Díaz-Casado E, Gómez-Nieto R, de Pereda JM, Muñoz LJ, Jara-Acevedo M, López DE (2020) "Analysis of gene variants in the GASH/Sal model of epilepsy." PLoS One 15(3):e0229953. [PubMed] [doi: 10.1371/journal.pone.0229953]

Usategui-Martín R, Gestoso-Uzal N, Calero-Paniagua I, De Pereda JM, Del Pino-Montes J, González-Sarmiento R. (2020) "A mutation in p62 protein (p. R321C), associated to Paget's disease of bone, causes a blockade of autophagy and an activation of NF-kB pathway." Bone 133:115265. [PubMed] [doi: 10.1016/j.bone.2020.115265]

Manso JA, Gómez-Hernández M, Carabias A, Alonso-García N, García-Rubio I, Kreft M, Sonnenberg A, de Pereda JM (2019) "Integrin α6β4 recognition of a linear motif of bullous pemphigoid antigen BP230 controls its recruitment to hemidesmosomes." Structure 27, 952-964. [PubMed] [doi: 10.1016/j.str.2019.03.016]
Also available in BioRxiv [doi: 10.1101/402123] and in Cell Press Sneak Peek [doi: 10.2139/ssrn.3330561].

Ortiz-Rivero S, Baquero C, Hernández-Cano L, Roldán-Etcheverry JJ, Gutiérrez-Herrero S, Fernández-Infante C, Martín-Granado V, Anguita E, de Pereda JM, Porras A, Guerrero C (2018) "C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation." Cell Commun. Signal. 16(1):101. [PubMed] [doi: 10.1186/s12964-018-0311-5]

Buey RM, Fernández-Justel D, de Pereda JM, Revuelta JL, Schürmann P, Buchanan BB, Balsera M. (2018) "Ferredoxin-linked flavoenzyme defines a family of pyridine nucleotide-independent thioredoxin reductases." PNAS 115(51):12967-12972. [PubMed] [doi: 10.1073/pnas.1812781115]

Buey RM, Arellano JB, López-Maury L, Galindo-Trigo S, Velázquez-Campoy A, Revuelta JL, de Pereda JM, Florencio FJ, Schürmann P, Buchanan BB, Balsera M (2017) "Unprecedented pathway of reducing equivalents in a diflavin-linked disulfide oxidoreductase." PNAS 114(48): 12725-12730. [PubMed] [doi: 10.1073/pnas.1713698114]

Balikov DA, Brady SK, Ko UH, Shin JH, de Pereda JM, Sonnenberg A, Sung H-J, Lang MJ (2017) "The nesprin-cytoskeleton interface probed directly on single nuclei is a mechanically rich system." Nucleus 8(5):534-547. [PubMed] [doi: 10.1080/19491034.2017.1322237]

Buey RM, Fernández-Justel D, Marcos-Alcalde I, Winter G, Gómez-Puertas P, de Pereda JM, Revuelta JL (2017) "A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases." Sci Rep 7(1):2648. [PubMed] [doi: 10.1038/s41598-017-02805-x]

Buey RM, Galindo-Trigo S, López-Maury L, Velázquez-Campoy A, Revuelta JL, Florencio FJ, de Pereda JM, Schürmann P, Buchanan BB, Balsera M (2017) "A New Member Of The Thioredoxin Reductase Family From Early Oxygenic Photosynthetic Organisms." Mol Plant 10(1):212-215. [PubMed] [doi: 10.1016/j.molp.2016.06.019]

Ortega E, Manso JA, Buey RM, Carballido AM, Carabias A, Sonnenberg A, de Pereda JM (2016) "The Structure of the Plakin Domain of Plectin Reveals an Extended Rod-like Shape." J Biol Chem 291(36), 18643-18662. [Abstract] [doi:10.1074/jbc.M116.732909]

Manso JA, García-Rubio I, Gómez-Hernández M, Ortega E, Buey RM, Carballido AM, Carabias A, Alonso-García N, de Pereda JM (2016) "Purification and Structural Analysis of Plectin and BPAG1e." Methods Enzymol 569:177-196. [Abstract] [doi:10.1016/bs.mie.2015.05.002]

Buey RM, Ledesma-Amaro R, Velazquez-Campoy A, Balsera M, Chagoyen M, de Pereda JM, Revuelta JL (2015) "Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases." Nat Commun 6,8923. [doi:10.1038/ncomms9923]

Buey RM, Ledesma-Amaro R, Balsera M, de Pereda JM, Revuelta JL (2015) "Increased riboflavin production by manipulation of inosine 5'-monophosphate dehydrogenase in Ashbya gossypii." Appl Microbiol Biotechnol 99(22):9577-9589. [doi:10.1007/s00253-015-6710-2]

Ketema M, Secades P, Kreft M, Nahidiazar L, Janssen H, Jalink K, de Pereda JM, Sonnenberg A (2015) "The rod domain is not essential for the function of plectin in maintaining tissue integrity." Mol Biol Cell 26(13):2402-2417. [Abstract] [doi:10.1091/mbc.E15-01-0043]

Alonso-García N, García-Rubio I, Manso JA, Buey RM, Urien H, Sonnenberg A, Jeschke G de Pereda JM, (2015) "Combination of X-ray crystallography, SAXS and DEER to obtain the structure of the FnIII-3,4 domains of integrin α6β4." Acta Cryst D 71(4):969-985. [doi:10.1107/S1399004715002485]

Sammito M, Millán C, Rodríguez DD, de Ilarduya IM, Meindl K, De Marino I, Petrillo G, Buey RM, de Pereda JM, Zeth K, Sheldrick GM, Usón I (2013) "Exploiting tertiary structure through local folds for crystallographic phasing." Nat Methods 10(11):1099-1101. [Abstract] [doi:10.1038/nmeth.2644]
Press note by CSIC (Spanish) (pdf)

Maia V, Ortiz-Rivero S, Sanz M, Gutierrez-Berzal J, Alvarez-Fernández I, Gutierrez-Herrero S, de Pereda JM, Porras A, Guerrero C (2013) "C3G forms complexes with Bcr-Abl and p38alpha MAPK at the focal adhesions in chronic myeloid leukemia cells: implication in the regulation of leukemic cell adhesion." Cell Commun Signal 11(1):9. [Abstract] [doi:10.1186/1478-811X-11-9]

de la Puerta ML, Trinidad AG, Rodríguez MdC, de Pereda JM, Sánchez Crespo M, Bayón Y, Alonso A (2013) "The Autoimmunity Risk Variant LYP-W620 Cooperates with CSK in the Regulation of TCR Signaling." Plos ONE 8(1): e54569. [Abstract] [doi:10.1371/journal.pone.0054569]

Buey RM, Sen I, Kortt O, Mohan R, Gfeller D, Veprintsev D, Kretzschmar I, Scheuermann J, Neri D, Zoete V, Michielin O, de Pereda JM, Akhmanova A, Volkmer R, Steinmetz MO. (2012) "Sequence determinants of a microtubule tip localization signal (MtLS)." J Biol Chem 287(34):28227-28242, [Abstract] [doi: 10.1074/jbc.M112.373928]

Ortega E, Buey RM, Sonnenberg A, de Pereda JM (2011) "The structure of the plakin domain of plectin reveals a non-canonical SH3 domain interacting with its fourth spectrin repeat." J Biol Chem 286(14):12429-12438, [Abstract] [doi: 10.1074/jbc.M110.197467]

Postel R, Ketema M, Kuikman I, de Pereda JM, Sonnenberg A (2011) "Nesprin-3 augments peripheral nuclear localization of intermediate filaments in zebrafish." J Cell Sci 124(Pt 5):755-764, [Abstract] [doi: 10.1242/jcs.081174]

de Pereda JM, Ortega E, Alonso-García N, Gómez-Hernández M, Sonnenberg A. (2009) "Advances and perspectives of the architecture of hemidesmosomes: Lessons from structural biology." Cell Adh Migr., 3(4):361-364. [Abstract] [doi:10.4161/cam.3.4.9525]

Alonso-García N, Inglés-Prieto A, Sonnenberg A, de Pereda JM (2009) "Structure of the Calx-β domain of the integrin β4: insights into function and cation-independent stability." Acta Cryst D., 65: 858-871. [doi:10.1107/S0907444909018745]

de Pereda JM*, Lillo MP, Sonnenberg A (2009) "Structural basis of the interaction between integrin alpha6beta4 and plectin at the hemidesmosomes" EMBO J., 28(8):1180-1190. [Abstract] [doi: 10.1038/emboj.2009.48]

Bayón Y, Trinidad AG, de la Puerta ML, Del Carmen Rodríguez M, Bogetz J, Rojas A, de Pereda JM, Rahmouni S, Williams S, Matsuzawa SI, Reed JC, Crespo MS, Mustelin T, Alonso A. (2008) "KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases." FEBS J., 275(5):3900-3910. [Abstract] [doi: 10.1111/j.1742-4658.2008.06537.x]

Sonnenberg A, Rojas AM, de Pereda JM. (2007) "The structure of a tandem pair of spectrin repeats of plectin reveals a modular organization of the plakin domain." J. Mol. Biol., 368(5):1379-1391. [Abstract] [doi: 10.1016/j.jmb.2007.02.090]

Litjens SH, de Pereda JM, Sonnenberg A. (2006) "Current insights into the formation and breakdown of hemidesmosomes." Trends Cell Biol., 16(7):376-383. [Abstract] [doi: 10.1016/j.tcb.2006.05.004]

Litjens SH, Wilhelmsen K, de Pereda JM, Perrakis A, Sonnenberg A. (2005) "Modeling and experimental validation of the binary complex of the plectin actin binding domain and the first pair of FNIII domains of the b4 integrin." J.Biol.Chem., 280(23):22270-22277. [Abstract] [Free full article] [doi: 10.1074/jbc.M411818200]

de Pereda JM, Wegener K, Santelli E, Bate N, Ginsberg MH, Critchley DR, Campbell ID, Liddington RC. (2005) "Structural basis for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions" J.Biol.Chem., 280(9):8381-8386. [Abstract] [doi: 10.1074/jbc.M413180200]

Lee HS, Bellin RM, Walker DL, Patel B, Powers P, Liu H, Garcia-Alvarez B, de Pereda JM, Liddington RC, Volkmann N, Hanein D, Critchley DR, Robson RM. (2004) "Characterization of an actin-binding site within the talin FERM domain" J.Mol.Biol. , 343(3):771-784. [Abstract] [doi: 10.1016/j.jmb.2004.08.069]

de Pereda, J.M., Waas, W.F., Jan, Y., Ruoslahti, E., Schimmel, P., Pascual, J. (2004) "Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity" J.Biol.Chem., 279(9):8111-8115. [Abstract] [doi: 10.1074/jbc.M311449200]

Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM., Ginsberg MH, Calderwood DA. (2003) "Talin binding to integrin beta tails: a final common step in integrin activation" Science, 302(5642):103-106. [Abstract] [doi: 10.1126/science.1086652]

Litjens SH, Koster J, Kuikman I, van Wilpe S, de Pereda JM., Sonnenberg A. (2003) "Specificity of binding of the plectin actin-binding domain to beta4 integrin" Mol Biol Cell, 14(10):4039-4050. [Abstract] [doi: 10.1091/mbc.e03-05-0268]

García-Alvarez, B., Bobkov, A., Sonnenberg, A., de Pereda, J.M. (2003) "Structural and Functional Analysis of the Actin Binding Domain of Plectin Suggests Alternative Mechanisms for Binding to F-Actin and Integrin beta4" Structure, 11(6) : 615-625 [Abstract] [doi: 10.1016/S0969-2126(03)00090-X]

Calderwood, D.A., Fujioka, Y., de Pereda, J.M., García-Alvarez, B., Nakamoto, T., Margolis, B., McGlade C.J., Liddington, R.C., Ginsberg, M.H.(2003) "Integrin beta cytoplasmic domain interactions with PTB domains: a structural prototype for diversity in integrin signaling" PNAS, 100(5) : 2272-72277. [Abstract] [doi: 10.1073/pnas.262791999]

Liddington, R.C., Bankston, L.A., de Pereda J.M. (2003) "Cell Adhesion: A FERM grasp of membrane Dynamics" Curr Biol. 13(3):R94-95. [Abstract] [doi: 10.1016/S0960-9822(03)00035-6]

García-Alvarez, B., de Pereda, J.M., Calderwood, D.A., Critchley, D.R., Ulmer, T.S., Campbell, I.D., Ginsberg, M.H., Liddington, R.C. (2003) "Structural determinants of integrin recognition by Talin" Mol Cell, 11(1):49-58. [Abstract] [doi: 10.1016/S1097-2765(02)00823-7]

Calderwood, D.A., Yan, B., de Pereda, J.M., García-Alvarez, B., Fujioka, Y., Liddington, R.C., and Ginsberg, M.H. (2002) "The Phosphotyrosine Binding-like Domain of Talin Activates Integrins." J. Biol. Chem., 277(24):21749-21758. [Abstract] [doi: 10.1074/jbc.M111996200]

Rodriguez, F., Harkins, S., Redwine, J.M., de Pereda, J.M., and Whitton, J.L. (2001) "CD4+ T cells induced by a DNA vaccine: immunological consequences of epitope-specific lysosomal targeting" J. Virol, 75(21):10421-10430. [Abstract] [doi: 10.1128/JVI.75.21.10421-10430.2001]

Bakolitsa,C., de Pereda, J.M., Bagshaw,C.R., Critchley, D.R., and Liddington, R.C.  (1999) "Crystal Structure of the Vinculin Tail Suggests a Pathway for Activation" Cell 99(6) : 603-613. [Abstract] [doi: 10.1016/S0092-8674(00)81549-4]

de Pereda, J.M., Wiche, G. and Liddington, R.C. (1999) "Crystal structure of a tandem pair of fibronectin type III domains from the cytoplasmic tail of integrin alpha6beta4" EMBO J. 18(15):4087-4095. [Abstract] [doi: 10.1093/emboj/18.15.4087]

Rezniczek, G.A., de Pereda, J.M., Reiper, S., and Wiche, G. (1998) "Linking integrin alpha6beta4-based cell adhesion to the intermediate filament of cytoskeleton: direct interaction between the beta4 subunit and plectin at multiple molecular sites" J. Cell Biol. 141(1) : 209-225. [Abstract] [Free full article] [doi: 10.1083/jcb.141.1.209]

de Pereda, J.M. and Andreu, J.M. (1996) "Mapping Surface Sequences of the Tubulin Dimer and Taxol-Induced Microtubules with Limited Proteolysis" Biochemistry 35(45): 14184-14201. [Abstract] [doi: 10.1021/bi961356j]

de Pereda, J.M., Leynadier, D. Evangelio, J.A., Chacón, P. and Andreu, J.M. (1996) "Tubulin Secondary Structure Analysis, Limited Proteolysis Sites, and Homology to FtsZ" Biochemistry 35(45): 14203-14215. [Abstract] [doi: 10.1021/bi961357b]

de Pereda, J.M., Wallin, M., Billger, M., and Andreu, J.M. (1995) "Comparative study of the colchicine binding site and assembly of fish and mammalian microtubule proteins" Cell Motility and the Cytoskeleton 30: 153-165. [Abstract] [doi: 10.1002/cm.970300207]

Andreu, J.M., Díaz, J.F., Gil, R., de Pereda, J.M., García de Lacoba, M., Peyrot, V.; Briand, C., Towns- Andrews, E., and Bordas, J. (1994) "Solution structure of Taxotere-induced microtubules to 3 nm resolution" J. Biol. Chem. 269(50):31785-31792. [Abstract] [Full article PDF file]

Andreu, J.M. and de Pereda, J.M. (1993) "Site directed antibodies to tubulin" Cell Motility and the Cytoskeleton 26:1-6. [Abstract] [doi: 10.1002/cm.970260102]