Knowledge of three-dimensional structure is all important and [...] the functions of living cells will never be understood without knowing the structures of the large molecules composing them.

We aim at understanding the structural basis of the molecular recognition mechanisms responsible for cell adhesion and signal transduction events.

Our studies focus on integrins, a family of cell adhesion receptors. Integrins play a major role in physiological and pathological processes, by regulating transduction pathways involved in cellular migration, proliferation, differentiation, and survival.

We use x-ray crystallography combined with other biophysical and biochemical techniques to study the cytoplasmic moieties of integrins and their interaction with signaling and structural molecules.